T Cell Epitope Peptide Therapy for Allergic Diseases
نویسندگان
چکیده
منابع مشابه
T Cell Epitope Peptide Therapy for Allergic Diseases
Careful selection of dominant T cell epitope peptides of major allergens that display degeneracy for binding to a wide array of MHC class II molecules allows induction of clinical and immunological tolerance to allergen in a refined treatment strategy. From the original concept of peptide-induced T cell anergy arising from in vitro studies, proof-of-concept murine models and flourishing human t...
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The predominant distribution of γ δ T cells in the mucosal and epithelial tissues makes these unconventional lymphocytes the "guards" to contact external environment (like allergens) and to contribute to immune surveillance, as well as "vanguards" to participate in initiating mucosal inflammation. Therefore, γ δ T cells have been considered to bridge the innate and adaptive immunity. The role t...
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ژورنال
عنوان ژورنال: Current Allergy and Asthma Reports
سال: 2016
ISSN: 1529-7322,1534-6315
DOI: 10.1007/s11882-015-0587-0